As early as 2012, foreign media reported a study by scientists from the University of Wisconsin Madison, saying that they proved in the laboratory that it can induce multi -purpose stem cells to grow into retina.
It has many characteristics of real retinal tissue, such as photosensitive cells, so it has been pinned on high expectations, such as the treatment of patients with vision damage or replacement of eye disease.
However, before turning into clinical applications, another question is needed to put them in the right place.
The double -sided micro -image of the tray / cylindrical pores supports the growth of cell tissue.
New ATLAS pointed out that macular degeneration is one of the main reasons for the loss of vision of adults, which is characterized by the optical cell hopes for patients’ eyes. Because of this, scientists have devoted a lot of efforts to find cell regeneration.
The good news is that a research team at UW-Madison University has provided a new “scaffolding” for the retina’s stem cell inducement and differentiation, which is expected to realize the replacement of intra-eye sensitivity cells in the future.
David Gamm, a professor of eye -catching science, said: Although there has been a breakthrough in the manufacturing of the “zero spare parts” of the sensor, we still need to try to put it in the correct position so that it can effectively rebuild the retina.
To this end, the research team invited the engineers with a world -class level and began to think about one thing -how to transport these cells in a more intelligent way?
Stem cells differentiated the light sensitive cells in ice -shaped pallet brackets.
It is reported that the researchers of the school have always been interested in how to use synthetic patch to fix the photoretically sensitive cells and then implant it into the damaged subtin film for regeneration.
Previous work has involved the use of wine glass -shaped pores to accommodate photosensitive cells. However, due to dissatisfaction with the number of cells that can be carried, the research team decided to continue to work in this regard.
In the end, we saw the second -generation ice -shaped light -shaped light cell tray. It not only increased density three times (a total of 300,000), but also designed cylindrical pores at the bottom to connect with the patient’s retina and gradually mature.
In terms of materials, it uses glycerol-seable with biocompatibility. It can provide the necessary mechanical strength in the early stage of the growth of photoretically sensitive cells, and be metabolized by the body safely after arriving at the destination.
Study with Figures -1: The manufacturing process of the Binge grid tray
The first work of the paper, the graduate student Allison Ludwig said: We hope that this material is very strong, but also hopes that it can quickly degrade in the eyes in about 2 months. This is particularly ideal for human retinal transplant replacement surgery.
With the improvement of technology, the research team will further optimize its shape and manufacturing technology. At present, it has prepared for related testing on large animals, and expects this technology to benefit all humanity as soon as possible.
Details on this study have been published in the journal of Science Advances, published recently.
The original title was “Ultrathin Micromolded 3D Scaffolds for High-Density PhotoreCeptor Layer Reconstruction”.